Título:	The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
Autor(es):	Morais, Rafael Martins de Barra Sobrinho, Alaor Silva, Calliandra Maria de Souza Oliveira, Jamila Reis de Silva, Izabel Cristina Rodrigues da Nóbrega, Otávio de Toledo
Assunto:	Tireóide - câncer
Data de publicação:	Nov-2018
Editora:	Hindawi
Referência:	MORAIS, Rafael Martins de et al. The role of the NIS (SLC5A5) gene in Papillary thyroid cancer: a systematic review. International Journal of Endocrinology, v. 2018, Article ID 9128754, 11 p. DOI: https://doi.org/10.1155/2018/9128754. Disponível em: https://www.hindawi.com/journals/ije/2018/9128754/. Acesso em: 25 fev. 2019.
Abstract:	Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Copyright © 2018 Rafael Martins de Morais et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	https://doi.org/10.1155/2018/9128754
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