Título:	The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
Autor(es):	Roll, Mariana Matos Vilela, Ana Luísa Miranda Longo, João Paulo Figueiró Agostini-Costa, Tânia da Silveira Grisolia, Cesar Koppe
Assunto:	Inflamação - envelhecimento Stress oxidativo Antioxidantes Medicina popular
Data de publicação:	2018
Editora:	Sociedade Brasileira de Genética
Referência:	ROLL, Mariana Matos et al . The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females. Genet. Mol. Biol., Ribeirão Preto , v. 41, n. 4, p. 858-869, Dec. 2018 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500858&lng=en&nrm=iso>. access on 30 Jan. 2019. Epub Nov 29, 2018. http://dx.doi.org/10.1590/1678-4685-gmb-2017-0218.
Abstract:	Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate in vivo the antioxidant and anti-inflammatory effects of pequi oil on hemogram and DNA damage in healthy young adult and older middle-aged Swiss mice of both genders. Animals, aged 6-7 and 11-12 months, were orally treated for 15 days with pequi oil at 30 mg/day. Blood samples were used for hemogram and comet assay, and bone marrow for micronucleus test. Female controls of 11-12 months had significantly lower haemoglobin and hematocrit than those of 6-7 months. Treatment with pequi oil improved this state, removing the differences. Pequi oil had no genotoxic or clastogenic effects and significantly increased lymphocytes and decreased neutrophils+monocytes in females of 11-12 months, removing the significant differences observed between controls of 6-7 and 11-12 months. The results suggest that dietary supplementation with pequi oil could protect against anemia, inflammation and oxidative stress related to aging, helping to prevent aging-related chronic degenerative diseases, mainly for females.
Licença:	License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
DOI:	http://dx.doi.org/10.1590/1678-4685-gmb-2017-0218
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