Título:	Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
Autor(es):	Vilela, Ana Luísa Miranda Akimoto, Arthur Kenji Alves, Penha Cristina Zaidan Hiragi, Cássia de Oliveira Penalva, Guilherme C. Oliveira, Silviene F. Grisolia, Cesar Koppe Guimarães, Maria de Nazaré Klautau
Assunto:	Etnicidade - Brasil Proteínas Polimorfismo (Genética)
Data de publicação:	Jun-2009
Editora:	Sociedade Brasileira de Genética
Referência:	MIRANDA-VILELA, Ana L. et al. Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities. Genetics and Molecular Biology, São Paulo, v. 32, n. 3, p. 456-461, jun. 2009. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300005&lng=en&nrm=iso>. Acesso em 25 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572009005000051.
Abstract:	Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp*2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp*1 allele has two subtypes, Hp*1F and Hp*1S, that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n = 70) and an urban population (n = 132) were determined by allele-specific PCR. The Hp*1F allele frequency was highest in Kalunga (29.3%) and lowest in Kayabi (2.6%). The Hp*1F/Hp*1S allele frequency ratios were 0.6, 1.0 and 0.26 for the Kayabi, Kalunga and urban populations, respectively. This variation was attributable largely to the Hp*1F allele. However, despite the large variation in Hp*1F frequencies, results of FST (0.0291) indicated slight genetic differentiation among subpopulations of the general Brazilian population studied here. This is the first Brazilian report of variations in the Hp *1F and Hp*1S frequencies among non-Amerindian Brazilians.
Licença:	Genetics and Molecular Biology - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000300005&lng=en&nrm=iso. Acesso em: 25 out. 2017.
DOI:	http://dx.doi.org/10.1590/S1415-47572009005000051
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