| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Souza, Gisele C. | pt_BR |
| dc.contributor.author | Franchi Jr., Gilberto C. | pt_BR |
| dc.contributor.author | Nowill, Alexandre E. | pt_BR |
| dc.contributor.author | Santos, Lourivaldo S. | pt_BR |
| dc.contributor.author | Alves, Cláudio N. | pt_BR |
| dc.contributor.author | Barata, Lauro E. S. | pt_BR |
| dc.contributor.author | Andrade, Carlos Kleber Zago de | pt_BR |
| dc.date.accessioned | 2018-01-04T19:14:43Z | - |
| dc.date.available | 2018-01-04T19:14:43Z | - |
| dc.date.issued | 2017-11 | pt_BR |
| dc.identifier.citation | SOUZA, Gisele C. et al. Synthesis, characterization and in vitro anticancer activity of Novel 8,4’-Oxyneolignan Analogues. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 11, p. 2229-2243, nov. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102229&lng=en&nrm=iso>. Acesso em: 1 fev. 2018. doi: http://dx.doi.org/10.21577/0103-5053.20170075. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/30697 | - |
| dc.language.iso | en | pt_BR |
| dc.publisher | Sociedade Brasileira de Química | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Synthesis, characterization and in vitro anticancer activity of Novel 8,4’ : oxyneolignan analogues | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Compostos orgânicos | pt_BR |
| dc.subject.keyword | Câncer - tratamento | pt_BR |
| dc.subject.keyword | Síntese | pt_BR |
| dc.rights.license | Journal of the Brazilian Chemical Society - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017001102229&lng=en&nrm=iso. Acesso em: 1 fev. 2017. | - |
| dc.identifier.doi | http://dx.doi.org/10.21577/0103-5053.20170075 | pt_BR |
| dc.description.abstract1 | Neolignans are a class of natural products with a wide range of biological effects. These substances are of great synthetic and biological interest, especially in searching for novel anticancer agents. In this paper, we report the synthesis of a new subclass of 8,4’-oxyneolignan analogues (β-ketoethers and β-ketoesters) and their cell viability assay on twenty four different cancer cells, among leukemias and carcinomas. Three compounds inhibited the growth of most human cancer cells. 2-Oxo-2-phenylethyl(2E)-3-[4-(2-oxo-2-phenylethoxy) phenyl]prop-2-enoate showed an antiproliferative activity superior to doxorubicin for U-87, U-138 MG and H1299 cell types and (E)-2-oxo-2-phenylethyl 3-(3-methoxy-4-(2-oxo-2-phenylethoxy)phenyl)acrylate was found to be very selective, demonstrating a growth inhibition of 92.0% against KG-1 cells. Furthermore, 1-oxo-1-phenylpropan-2-yl cinnamate exhibited significant inhibition activity in a range of 52.2 to 91.2% against twelve kinds of leukemia cell lines, revealing excellent results and very comparable to the reference drug. | - |
| dc.description.unidade | Instituto de Química (IQ) | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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