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dc.contributor.authorSoares, Marco Aurélio-
dc.contributor.authorAraújo, Roberta Amália de Carvalho-
dc.contributor.authorMarini, Marjorie Mendes-
dc.contributor.authorOliveira, Luciana Márcia de-
dc.contributor.authorLima, Leonardo Gomes de-
dc.contributor.authorAlves, Viviane de Souza-
dc.contributor.authorFelipe, Maria Sueli Soares-
dc.contributor.authorBrígido, Marcelo de Macedo-
dc.contributor.authorSoares, Célia Maria de Almeida-
dc.contributor.authorSilveira, José Franco da-
dc.contributor.authorRuiz, Jerônimo Conceição-
dc.contributor.authorCisalpino, Patrícia Silva-
dc.date.accessioned2017-08-22T12:49:21Z-
dc.date.available2017-08-22T12:49:21Z-
dc.date.issued2015-05-12-
dc.identifier.citationSOARES, Marco Aurélio et al. Identification and characterization of expressed retrotransposons in the genome of the Paracoccidioides species complex. BMC Genomics, v. 16, Article 376, 12 mai. 2015. Disponível em: <https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1564-7>. Acesso em: 27 jun. 2017. doi: https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1564-7.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/24207-
dc.language.isoInglêspt_BR
dc.publisherBioMed Centralpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleIdentification and characterization of expressed retrotransposons in the genome of the Paracoccidioides species complexpt_BR
dc.typeArtigopt_BR
dc.subject.keywordParacoccidioidespt_BR
dc.subject.keywordFungospt_BR
dc.subject.keywordAmérica Latinapt_BR
dc.subject.keywordGenomapt_BR
dc.rights.license© 2015 Soares et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.pt_BR
dc.identifier.doihttps://dx.doi.org/10.1186/s12864-015-1564-7pt_BR
dc.description.abstract1Background: Species from the Paracoccidioides complex are thermally dimorphic fungi and the causative agents of paracoccidioidomycosis, a deep fungal infection that is the most prevalent systemic mycosis in Latin America and represents the most important cause of death in immunocompetent individuals with systemic mycosis in Brazil. We previously described the identification of eight new families of DNA transposons in Paracoccidioides genomes. In this work, we aimed to identify potentially active retrotransposons in Paracoccidioides genomes. Results: We identified five different retrotransposon families (four LTR-like and one LINE-like element) in the genomes of three Paracoccidioides isolates. Retrotransposons were present in all of the genomes analyzed. P. brasiliensis and P. lutzii species harbored the same retrotransposon lineages but differed in their copy numbers. In the Pb01, Pb03 and Pb18 genomes, the number of LTR retrotransposons was higher than the number of LINE-like elements, and the LINE-like element RtPc5 was transcribed in Paracoccidioides lutzii (Pb01) but could not be detected in P. brasiliensis (Pb03 and Pb18) by semi-quantitative RT-PCR. Conclusion: Five new potentially active retrotransposons have been identified in the genomic assemblies of the Paracoccidioides species complex using a combined computational and experimental approach. The distribution across the two known species, P. brasiliensis and P. lutzii, and phylogenetics analysis indicate that these elements could have been acquired before speciation occurred. The presence of active retrotransposons in the genome may have implications regarding the evolution and genetic diversification of the Paracoccidioides genus.pt_BR
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