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dc.contributor.authorTeixeira, Marcus de Melo-
dc.contributor.authorAlmeida, Luiz G. P. de-
dc.contributor.authorBarreira, Paula Kubitschek-
dc.contributor.authorAlves, Fernanda L.-
dc.contributor.authorKioshima, Érika Seki-
dc.contributor.authorAbadio, Ana Karina Rodrigues-
dc.contributor.authorFernandes, Larissa-
dc.contributor.authorDerengowski, Lorena da Silveira-
dc.contributor.authorFerreira, Karen Spadari-
dc.contributor.authorSouza, Rangel C.-
dc.contributor.authorRuiz, Jerônimo Conceição-
dc.contributor.authorAndrade, Nathália Curty De-
dc.contributor.authorPaes, Hugo Costa-
dc.contributor.authorNicola, André Moraes-
dc.contributor.authorAlbuquerque, Patrícia-
dc.contributor.authorGerber, Alexandra Lehmkuhl-
dc.contributor.authorMartins, Vicente de Paulo-
dc.contributor.authorPeconick, Luísa Defranco Ferreira-
dc.contributor.authorViggiano Neto, Alan-
dc.contributor.authorChaucanez, Claudia B.-
dc.contributor.authorSilva, Patrícia Alves-
dc.contributor.authorCunha, Oberdan L.-
dc.contributor.authorOliveira, Fabiana Freire Mendes de-
dc.contributor.authorSantos, Tayná Cristina dos-
dc.contributor.authorBarros, Amanda Lira Nogueira-
dc.contributor.authorSoares, Marcos Antônio-
dc.contributor.authorOliveira, Luciana M. de-
dc.contributor.authorMarini, Marjorie Mendes-
dc.contributor.authorDuno, Héctor Villalobos-
dc.contributor.authorCunha, Marcel Menezes Lyra da-
dc.contributor.authorHoog, Sybren de-
dc.contributor.authorSilveira, José Franco da-
dc.contributor.authorHenrissat, Bernard-
dc.contributor.authorNiño Vega, Gustavo A.-
dc.contributor.authorCisalpino, Patrícia Silva-
dc.contributor.authorMontes, Héctor Manuel Mora-
dc.contributor.authorAlmeida, Sandro Rogério de-
dc.contributor.authorStajich, Jason E.-
dc.contributor.authorBezerra, Leila Maria Lopes-
dc.contributor.authorVasconcelos, Ana Tereza Ribeiro de-
dc.contributor.authorFelipe, Maria Sueli Soares-
dc.date.accessioned2017-07-10T11:42:56Z-
dc.date.available2017-07-10T11:42:56Z-
dc.date.issued2014-09-25-
dc.identifier.citationTEIXEIRA, Marcus de Melo et al. Comparative genomics of the major fungal agents of human and animal Sporotrichosis: Sporothrix schenckii and Sporothrix brasiliensis. BMC Genomics, v. 15, Article 943, 25 set. 2014. Disponível em: <https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-943>. Acesso em: 12 jun. 2017. doi: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-943.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/23801-
dc.language.isoInglêspt_BR
dc.publisherBioMed Centralpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleComparative genomics of the major fungal agents of human and animal Sporotrichosis : Sporothrix schenckii and Sporothrix brasiliensispt_BR
dc.typeArtigopt_BR
dc.subject.keywordFungos - doençaspt_BR
dc.subject.keywordGatopt_BR
dc.subject.keywordPlantaspt_BR
dc.rights.license© 2014 Teixeira et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.pt_BR
dc.identifier.doihttps://dx.doi.org/10.1186/1471-2164-15-943pt_BR
dc.description.abstract1Background: The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliensis; 2) to compare S. brasiliensis, which is cat-transmitted and infects both humans and cats with S. schenckii, mainly a human pathogen; 3) to compare these two species to other human pathogens (Onygenales) with similar thermo-dimorphic behavior and to other plant-associated Sordariomycetes. Results: The genomes of S. schenckii and S. brasiliensis were pyrosequenced to 17x and 20x coverage comprising a total of 32.3 Mb and 33.2 Mb, respectively. Pair-wise genome alignments revealed that the two species are highly syntenic showing 97.5% average sequence identity. Phylogenomic analysis reveals that both species diverged about 3.8-4.9 MYA suggesting a recent event of speciation. Transposable elements comprise respectively 0.34% and 0.62% of the S. schenckii and S. brasiliensis genomes and expansions of Gypsy-like elements was observed reflecting the accumulation of repetitive elements in the S. brasiliensis genome. Mitochondrial genomic comparisons showed the presence of group-I intron encoding homing endonucleases (HE’s) exclusively in S. brasiliensis. Analysis of protein family expansions and contractions in the Sporothrix lineage revealed expansion of LysM domain-containing proteins, small GTPases, PKS type1 and leucin-rich proteins. In contrast, a lack of polysaccharide lyase genes that are associated with decay of plants was observed when compared to other Sordariomycetes and dimorphic fungal pathogens, suggesting evolutionary adaptations from a plant pathogenic or saprobic to an animal pathogenic life style. Conclusions: Comparative genomic data suggest a unique ecological shift in the Sporothrix lineage from plantassociation to mammalian parasitism, which contributes to the understanding of how environmental interactions may shape fungal virulence. . Moreover, the striking differences found in comparison with other dimorphic fungi revealed that dimorphism in these close relatives of plant-associated Sordariomycetes is a case of convergent evolution, stressing the importance of this morphogenetic change in fungal pathogenesis.pt_BR
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