Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients

Lozano, Viviane Furlan; Lins, Tulio Cesar de Lima; Teixeira, Marcus de Melo; Vieira, Rodrigo G.; Blotta, Maria Heloisa de Souza Lima; Goes, Alfredo Miranda de; Silva, Izabel Cristina Rodrigues da; Pereira, Rinaldo Wellerson; Bocca, Anamélia Lorenzetti; Felipe, Maria Sueli Soares

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Campo DC	Valor	Idioma
dc.contributor.author	Lozano, Viviane Furlan	-
dc.contributor.author	Lins, Tulio Cesar de Lima	-
dc.contributor.author	Teixeira, Marcus de Melo	-
dc.contributor.author	Vieira, Rodrigo G.	-
dc.contributor.author	Blotta, Maria Heloisa de Souza Lima	-
dc.contributor.author	Goes, Alfredo Miranda de	-
dc.contributor.author	Silva, Izabel Cristina Rodrigues da	-
dc.contributor.author	Pereira, Rinaldo Wellerson	-
dc.contributor.author	Bocca, Anamélia Lorenzetti	-
dc.contributor.author	Felipe, Maria Sueli Soares	-
dc.date.accessioned	2013-03-27T20:39:20Z	-
dc.date.available	2013-03-27T20:39:20Z	-
dc.date.issued	2011-03	-
dc.identifier.citation	LOZANO, Viviane F. et al. Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 2, mar. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200017&lng=pt&nrm=iso&tlng=en>. Acesso em: 21 mar. 2013. http://dx.doi.org/10.1590/S0074-02762011000200017.	en
dc.identifier.uri	http://repositorio.unb.br/handle/10482/12627	-
dc.language.iso	Inglês	en
dc.publisher	Instituto Oswaldo Cruz, Ministério da Saúde	en
dc.rights	Acesso Aberto	en
dc.title	Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients	en
dc.type	Artigo	en
dc.subject.keyword	Paracoccidioides brasiliensis	en
dc.subject.keyword	Paracoccidioidomicose	en
dc.subject.keyword	Fungos patogênicos	en
dc.rights.license	Memórias do Instituto Oswaldo Cruz - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200017&lng=pt&nrm=iso&tlng=en. Acesso em: 21 mar. 2013.	en
dc.identifier.doi	http://dx.doi.org/10.1590/S0074-02762011000200017	en
dc.description.abstract1	The CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1 and paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. For this purpose, 66 chronic form PCM patients and 76 healthy controls had their allele, genotype and haplotype frequencies determined. The genetic admixture structure of the patients and controls was evaluated to eliminate ancestral bias. The comparison of frequencies indicated no significant differences between patients and controls that could link the SNPs to PCM. Groups were admixture matched with no difference observed in population ancestry inference, indicating that the absence of association between CTLA-4 polymorphisms and PCM could not be attributed to ancestral bias. This study showed that there was no association between the CTLA-4 SNPs -318 and +49 and the resistance or susceptibility to PCM.	-
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