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Title: Enterolobin induces rat paw oedema independently of PAF-Acether
Authors: Faria Neto, Hugo Caire de Castro
Cordeiro, Renato Sergio Balao
Martins, Marco Aurélio
Silva, A. C. V. Correira da
Bozza, Patricia Torres
Sousa, Marcelo Valle de
Morhy, Lauro
Assunto:: Proteínas
Edema
Issue Date: 1991
Citation: FARIA NETO, H. C. Castro et al. Enterolobin induces rat paw oedema independently of PAF-Acether. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, n. supl.II, p. 129-131, 1991.Disponível em: <http://www.scielo.br/pdf/mioc/v86s2/vol86(fsup2)_126-128.pdf>. Acesso em: 16 nov. 2011.
Abstract: The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin (5-20 µg/paw) yielded a dose response curve for oedema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24 h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was perfomed. The oedema triggered by enterolobin was not modified in PAF desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.
Licença:: "Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=0074-0276&nrm=iso&rep=&lng=pt. Acesso em: 16 nov. 2011.
Appears in Collections:CEL - Artigos publicados em periódicos

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