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Title: Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles : assessment of biocompatibility and potential applications
Authors: Silva, Luisa H. A.
Silva, Jaqueline R. da
Ferreira, Guilherme A.
Silva, Renata C.
Lima, Emilia Celma de Oliveira
Azevedo, Ricardo Bentes de
Oliveira, Daniela M.
Assunto:: Células-tronco
Nanopartículas
Biocompatibilidade
Issue Date: Jul-2016
Publisher: BioMed Central
Citation: SILVA, Luisa H. A. et al. Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles: assessment of biocompatibility and potential applications. Journal of Nanobiotechnology, v. 14, jul. 2016. DOI: https://doi.org/10.1186/s12951-016-0213-x. Disponível em: https://jnanobiotechnology.biomedcentral.com/track/pdf/10.1186/s12951-016-0213-x. Acesso em: 14 dez. 2018.
Abstract: Nanoparticles’ unique features have been highly explored in cellular therapies. However, nanoparticles can be cytotoxic. The cytotoxicity can be overcome by coating the nanoparticles with an appropriated surface modification. Nanoparticle coating influences biocompatibility between nanoparticles and cells and may affect some cell properties. Here, we evaluated the biocompatibility of gold and maghemite nanoparticles functionalized with 2,3-dimercaptosuccinic acid (DMSA), Au-DMSA and γ-Fe2O3-DMSA respectively, with human mesenchymal stem cells. Also, we tested these nanoparticles as tracers for mesenchymal stem cells in vivo tracking by computed tomography and as agents for mesenchymal stem cells magnetic targeting.
Licença:: © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI: https://doi.org/10.1186/s12951-016-0213-x
Appears in Collections:GEM - Artigos publicados em periódicos

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