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Título: A validated NMR approach for MDMA quantification in Ecstasy tablets
Autor(es): Almeida, Nathalia S.
Benedito, Luiz E. C.
Maldaner, Adriano Otávio
Oliveira, Aline Lima de
Assunto: Drogas
MDMA
qNMR
Análise forense
Validação
Data de publicação: Set-2018
Editora: Sociedade Brasileira de Química
Referência: ALMEIDA, Nathalia S. et al . A validated NMR approach for MDMA quantification in ecstasy tablets. Journal of the Brazilian Chemical Society, São Paulo, v. 29, n. 9, p. 1944-1950, set. 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000901944&lng=en&nrm=iso>. Acesso em: 30 out. 2018. doi: http://dx.doi.org/10.21577/0103-5053.20180071.
Abstract: In recent years, ecstasy trafficking has grown in complexity and tablets has been commonly sold containing different contents of 3,4-methylenedioxymethamphetamine (MDMA) or even other psychoactive substances. In contrast, identification and quantification of drugs of abuse is still a challenge, once the access to drug standards is very restricted in Brazil. In this work, ecstasy tablets seized by the Brazilian Federal Police have their chemical composition identified and quantified by gas chromatography and quantitative 1H nuclear magnetic resonance based on an internal standard approach (IS-1H-qNMR). Both methods were validated and showed suitable results for the figures of merit. IS-1H-qNMR shows excellent results of accuracy (relative error < 5%) and precision (relative standard deviation (RSD) < 2%). Comparatively, IS-1H-qNMR is more efficient and versatile than gas chromatography to accomplish in a single analysis the identification and quantification of target analytes. Since the method does not require a specific reference material, it is cost effective and provides agility to routine forensic analysis.
Licença: Journal of the Brazilian Chemical Society - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000901944. Acesso em: 30 out. 2018.
DOI: http://dx.doi.org/10.21577/0103-5053.20180071
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