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Título: Vouacapane diterpenoids isolated from Pterodon and their biological activities
Autor(es): Oliveira, Leandra A.R.
Oliveira, Gerlon A.R.
Borges, Leonardo L.
Bara, Maria Teresa F.
Silveira, Dâmaris
Assunto: Atividade biológica
Fitoquímica
Sucupira
Data de publicação: Set-2017
Editora: Sociedade Brasileira de Farmacognosia
Referência: OLIVEIRA, Leandra A.R. et al. Vouacapane diterpenoids isolated from Pterodon and their biological activities. Revista Brasileira de Farmacognosia, Curitiba, v. 27, n. 5, p. 663-672, set./out. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500663&lng=en&nrm=iso>. Acesso em: 15 fev. 2018. doi: http://dx.doi.org/10.1016/j.bjp.2017.05.014.
Abstract: The Pterodon genus comprises two native species in Brazil, known as “sucupira-branca” or “faveira”. Their fruits have long been used in Brazilian natural medicine, mainly for the treatment of infections and inflammations. The pharmacological properties of these fruits have often been linked with vouacapane diterpenoids. This review evaluated the scientific research in the period from 1973 to February 2017, aiming to answer how difficult it still is to develop a scientifically supported product based on Pterodon vouacapanes. Therefore, this paper reviews purification, identification, and quantification methods applied to vouacapane diterpenoids from Pterodon, as well as the performance of these phytochemicals in pharmacological tests described in the literature. Data analysis results support conventional notions that suggest vouacapane diterpenoids from Pterodon have anti-inflammatory properties. However, the studies carried out so far still represent partial assessment of the vouacapane activities and further studies need to be completed. Pterodon diterpenoids have also been associated with larvicidal, leishmanicidal, cardiovascular, and antitumor activities, which reinforces the genus' potential as a source of phytomedicines. Some remaining gaps about the reviewed activities were mentioned, while trends and perspectives for future research were proposed.
Licença: Revista Brasileira de Farmacognosia - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000500663&lng=en&nrm=iso. Acesso em: 15 fev. 2018.
DOI: http://dx.doi.org/10.1016/j.bjp.2017.05.014
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