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ARTIGO_Iontophoresis on minoxidilSulphateLoaded.pdf743,81 kBAdobe PDFVisualizar/Abrir
Título: Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles
Autor(es): Matos, Breno N.
Melo, Larissa M. A.
Pereira, Maíra N.
Reis, Thaiene A.
Cunha-Filho, Marcílio
Gratieri, Taís
Gelfuso, Guilherme Martins
Assunto: Quitosana
Nanopartículas
Pele
Data de publicação: Fev-2017
Editora: Sociedade Brasileira de Química
Referência: MATOS, Breno N. et al. Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles. Química Nova, São Paulo, v. 40, n. 2, p. 154-157, fev. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000200154&lng=en&nrm=iso>. Acesso em: 21 fev. 2018. doi: http://dx.doi.org/10.21577/0100-4042.20160159.
Abstract: The experiments described in this paper tested the hypothesis whether iontophoresis applied on a chitosan nanoparticle formulation could combine the enhanced drug accumulation into the follicular casts obtained using iontophoresis and the sustained drug release, reducing dermal exposure, provided by nanoparticles. Results showed that even though iontophoresis presented comparable minoxidil targeting potential to hair follicles than passive delivery of chitosan-nanoparticles (4.1 ± 0.9 and 5.3 ± 1.0 µg cm-2, respectively), it was less effective on preventing dermal exposure, since chitosan-nanoparticles presented a drug permeation in the receptor solution of 15.3 ± 4.3 µg cm-2 after 6 h of iontophoresis, while drug amounts from passive nanoparticle delivery were not detected. Drug release experiments showed particles were not able to sustain the drug release under the influence of a potential gradient. In conclusion, the application of MXS-loaded chitosan nanoparticles remains the best way to target MXS to the hair follicles while preventing dermal exposure.
Licença: Química Nova - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017000200154&lng=en&nrm=iso. Acesso em: 21 fev. 2018.
DOI: http://dx.doi.org/10.21577/0100-4042.20160159
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