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Title: Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus : implications for field studies
Authors: Cruz, Helena Medina
Scalioni, Leticia de Paula
Paula, Vanessa Salete de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Milagres, Flavio Augusto Pádua
Cruz, Marcelo Santos
Bastos, Francisco Inácio
Flores, Priscila Pollo
Leal, Erotildes
Motta-Castro, Ana Rita Coimbra
Lewis-Ximenez, Lia Laura
Lampe, Elisabeth
Villar, Livia Melo
Assunto:: Hepatite B
Issue Date: Mar-2017
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: CRUZ, Helena Medina et al. Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 209-213, mar. 2017. Disponível em: <>. Acesso em: 22 fev. 2018. Epub Jan 30, 2017. doi:
Abstract: Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.
Licença:: Memórias do Instituto Oswaldo Cruz - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: Acesso em: 22 fev. 2018.
Appears in Collections:FMD - Artigos publicados em periódicos

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