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Title: Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
Authors: Alecrim, Hugo Muscelli
Duarte, Sérgio Andurte Carvalho
Amaral, Maria Eduarda Bonavides
Diógenis, Filipe
Carneiro, Fabiana Pirani
Sousa, João Batista de
Assunto:: Cólon (Anatomia)
Cicatrização de feridas
Cirurgia
Ratos
Issue Date: Jan-2015
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citation: ALECRIM, Hugo Muscelli et al. Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 1, p. 73-79, jan. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-86502015001000010.
Abstract: Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats.
Licença:: Acta Cirurgica Brasileira - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso. Acesso em: 17 abr. 2018.
DOI: http://dx.doi.org/10.1590/S0102-86502015001000010
Appears in Collections:FMD - Artigos publicados em periódicos

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