Skip navigation
Please use this identifier to cite or link to this item: http://repositorio.unb.br/handle/10482/28805
Files in This Item:
File SizeFormat 
v28n9a08.pdf2,07 MBAdobe PDFView/Open
Title: The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats
Authors: Durães, Leonardo de Castro
Farias, Igor Eduardo Caetano de
Morais, Pedro Henrique Alves de
Oliveira, Paulo Gonçalves de
Cavalcanti Neto, Florêncio Figueiredo
Lino Junior, Ruy Souza
Feres, Omar
Sousa, João Batista de
Assunto:: Pneumoperitoneum, Artificial
Carbon Dioxide
Anastomosis, Surgical
Wound Healing
Colon
Rats
Issue Date: 2013
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citation: Acta Cir. Bras.,v.28,n.9,p.670-677,2013
Abstract: PURPOSE: To investigate the effects of pneumoperitoneum on colonic anastomosis healing. METHODS: Colonic anastomosis was performed in 120 rats divided into four groups: Group I - pneumoperitoneum before laparotomy, Group II - pneumoperitoneum after laparorrhaphy, Group III - pneumoperitoneum before laparotomy and after laparorrhaphy, Group IV - no pneumoperitoneum (control group). Pneumoperitoneum pressure was 5 mmHg. Animals were killed on the 3rd, 7th and 14th postoperative day. Hhistopathological features, anastomosis breaking strength, collagen histomorphometry and hydroxyproline concentration were assessed. RESULTS: Breaking strength between groups: (day 3, p=0.165; day 7, p=0.219; day 14, p=0.539). Histopathology revealed that group II had, on day 7, less infiltration of mononuclear cells (p=0.006), greater infiltration of polymorphonuclear cells (p=0.001) and greater necrosis (p=0.001); and on day 14, less fibrosis. Histomorphometry revealed a decrease in collagen in groups I and III (p<0.001) on day 7 and an increase in groups I and II on day 14 (p<0.001). Hydroxyproline concentration was similar for groups on days 3 (p=0.152), 7 (p=0.913) or 14 (p=0.981). CONCLUSION: Carbon dioxide does not impair the healing of colonic anastomosis in rats.
DOI: https://dx.doi.org/10.1590/S0102-86502013000900008
Appears in Collections:Uso interno - em processamento

Show full item record Recommend this item " class="statisticsLink btn btn-primary" href="/handle/10482/28805/statistics">



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.