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Title: Pentavalent antimonial nephrotoxicity in the rat
Other Titles: Disfunção tubular renal em ratos tratados com antimoniais pentavalentes
Authors: Veiga, Joel Paulo Russomano
Khanam, Rashida
Rosa, Tânia Torres
Junqueira Junior, Luiz Fernando
Brant, Plínio Caldeira
Raick, Alberto Nicolau
Friedman, Horacio
Marsden, Philip Davis
Assunto:: Rins - doenças
Rins - necrose
Ratos
Issue Date: Aug-1990
Publisher: Instituto de Medicina Tropical
Citation: VEIGA, Joel Paulo R. et al. Pentavalent antimonial nephrotoxicity in the rat. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 32, n. 4, p. 304-309, ago. 1990. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651990000400012&lng=en&nrm=iso>. Acesso em: 06 nov. 2017. doi: http://dx.doi.org/10.1590/S0036-46651990000400012.
Abstract: Estudou-se a função renal de ratos tratados com Glucantime (Antimoniato de Meglumine, Rhodia) e Pentostam (Estibogluconato de Sódio, Wellcome) na dose de 30 mg de Sb v por 100 g de peso por dia, durante 30 dias. Observou-se um distúrio na concentração urinária, que foi reversível 7 dias após cessada a administração das drogas. O estudo histopatológico do rim, por meio da microscopia óptica, não evidenciou alterações significativas. Por outro lado, ratos tratados com altas doses dos antimoniais (200 mg de Sb v por 100 g de peso por dia) mostraram alterações funcionais e histopatológicas renais compatíveis com necrose tubular aguda.
Abstract: Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sb v (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis.
Licença:: Revista do Instituto de Medicina Tropical de São Paulo - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651990000400012&lng=en&nrm=iso. Acesso em: 06 nov. 2017.
DOI: http://dx.doi.org/10.1590/S0036-46651990000400012
Appears in Collections:FMD - Artigos publicados em periódicos

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