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Title: Antiviral activity of animal venom peptides and related compounds
Authors: Mata, Élida Cleyse Gomes da Mata
Mourão, Caroline Barbosa Farias
Rangel, Marisa
Schwartz, Elisabeth Nogueira Ferroni
Assunto:: Agentes antirretrovirais
HIV (Vírus)
Escorpião - veneno
Cobras venenosas - veneno
Anfíbio - veneno
Inseto - veneno
Fauna marinha
Peptídeos
Issue Date: 6-Jan-2017
Publisher: BioMed Central
Citation: MATA, Élida Cleyse Gomes da Mata et al. Antiviral activity of animal venom peptides and related compounds. The Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 23, n. 3, p. 1-12, 6 jan. 2017. Disponível em: <https://jvat.biomedcentral.com/articles/10.1186/s40409-016-0089-0>. Acesso em: 27 jul. 2017. doi: https://doi.org/10.1186/s40409-016-0089-0.
Abstract: Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals. Venoms are complex mixtures of hundreds of molecules, mostly peptides, that present a large array of biological activities and evolved to putatively target the biochemical machinery of different pathogens or host cellular structures. In addition, non-venomous compounds, such as some body fluids of invertebrate organisms, exhibit antiviral activity. This review provides a panorama of peptides described from animal venoms that present antiviral activity, thereby reinforcing them as important tools for the development of new therapeutic drugs.
Licença:: © The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI: https://doi.org/10.1186/s40409-016-0089-0
Appears in Collections:CFS - Artigos publicados em periódicos

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