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dc.contributor.authorSilva, Silvana Marques e-
dc.contributor.authorJerônimo, Márcio Sousa-
dc.contributor.authorPereira, Ildinete da Silva-
dc.contributor.authorTavares, Aldo Henrique Fonseca Pacheco-
dc.contributor.authorBocca, Anamélia Lorenzetti-
dc.contributor.authorSousa, João Batista de-
dc.date.accessioned2017-08-21T14:59:00Z-
dc.date.available2017-08-21T14:59:00Z-
dc.date.issued2015-11-
dc.identifier.citationSILVA, Silvana Marques et al. Effects of metoclopramide on the expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study. Acta Cirurgica Brasileira, v. 30, n. 11, p. 763, nov. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015001100762>. Acesso em: 10 jul. 2017. doi: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015001100762.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/24199-
dc.language.isoInglêspt_BR
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgiapt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEffects of metoclopramide on the expression of metalloproteinases and interleukins in left colonic anastomoses : an experimental studypt_BR
dc.typeArtigopt_BR
dc.subject.keywordAnastomosept_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordSepticemiapt_BR
dc.subject.keywordRatopt_BR
dc.rights.licenseActa Cirurgica Brasileira - This is an open-access article distributed under the terms of the Creative Commons Attribution License (Attribution 4.0 International (CC BY 4.0)). Fonte: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015001100762>. Acesso em: 10 jul. 2017.pt_BR
dc.identifier.doihttps://dx.doi.org/10.1590/S0102-865020150110000007pt_BR
dc.description.abstract1PURPOSE: To evaluate the effects of metoclopramide on metalloproteinases (MMP) and interleukins (IL) gene expression in colonic anastomoses in rats. METHODS: Eighty rats were divided into two groups for euthanasia on the 3rd or 7th postoperative day (POD), then into two subgroups for sepsis induction or not, and then into subgroups to receive either metoclopramide or saline solution. Left colonic anastomosis were performed and then analyzed. RESULTS : On the 3rd POD, metoclopramide was associated with increased expression of MMP-1a, MMP-13, and TNF-α. On the 7th POD, the transcripts of all MMPs, TNF-α, IL-1β, IFN-γ, and IL-10 of the treated animals became negatively modulated. In the presence of sepsis, metoclopramide did not change MMPs and decreased IL-6, IL-1β, IFN-γ and IL-10 gene expression on the 3rd POD. On the 7th POD, increased expression of all MMPs, IFN-γ and IL-10 and negative modulated TNF-α and IL-6 gene expression. CONCLUSION: Administration of metoclopramide increased metalloproteinases and interleukins gene expression on the 3rd postoperative day and negatively modulated them on the 7th POD. In the presence of abdominal sepsis, metoclopramide did not change MMPs and decreased ILs gene expression on the 3rd POD. On the 7th POD, the drug increased expression of all MMPs.pt_BR
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