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Title: The scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 opening
Authors: Camargos, Thalita Soares
Bosmans, Frank
Rego, Solange Cristina
Mourão, Caroline Barbosa Farias
Schwartz, Elisabeth Nogueira Ferroni
Assunto:: Escorpião
Toxinas
Mamífero
Issue Date: 17-Jun-2015
Publisher: Plos One
Citation: CAMARGOS, Thalita Soares et al. The scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 opening. Plos One, v. 10, n. 6, Article e0128578, 17 jun. 2015. Disponível em: <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128578>. Acesso em: 20 jun. 2017. doi: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128578.
Abstract: We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis.We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function.
Licença:: Copyright: © 2015 Camargos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: https://dx.doi.org/10.1371/ journal.pone.0128578
Appears in Collections:CFS - Artigos publicados em periódicos

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