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Title: Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system
Authors: Estevanato, Luciana Landim Carneiro
Cintra, Débora
Baldini, Nayara
Portilho, Flávia
Barbosa, Luzirlane dos Santos
Martins, Olímpia
Lacava, Bruno Marques
Miranda-Vilela, Ana Luisa
Tedesco, Antonio Claudio
Báo, Sônia Nair
Morais, Paulo César de
Lacava, Zulmira Guerrero Marques
Assunto:: Nanopartículas
Cérebro
Issue Date: 2011
Publisher: International Journal of Nanomedicine
Citation: ESTEVANATO, Luciana Landim Carneiro, et al. Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system. International Journal of Nanomedicine, v. 6, p. 1709-1717, 2011. Disponível em:<http://www.dovepress.com/preliminary-biocompatibility-investigation-of-magnetic-albumin-nanosph-peer-reviewed-article-IJN>. Acesso em: 03 fev. 2015.
Abstract: Background: The magnetic albumin nanosphere (MAN), encapsulating maghemite nanoparticles, was designed as a magnetic drug delivery system (MDDS) able to perform a variety of biomedical applications. It is noteworthy that MAN was efficient in treating Ehrlich’s tumors by the magnetohyperthermia procedure. Methods and materials: In this study, several nanotoxicity tests were systematically carried out in mice from 30 minutes until 30 days after MAN injection to investigate their biocompatibility status. Cytometry analysis, viability tests, micronucleus assay, and histological analysis were performed. Results: Cytometry analysis and viability tests revealed MAN promotes only slight and temporary alterations in the frequency of both leukocyte populations and viable peritoneal cells, respectively. Micronucleus assay showed absolutely no genotoxicity or cytotoxicity effects and histological analysis showed no alterations or even nanoparticle clusters in several investigated organs but, interestingly, revealed the presence of MAN clusters in the central nervous system (CNS). Conclusion: The results showed that MAN has desirable in vivo biocompatibility, presenting potential for use as a MDDS, especially in CNS disease therapy.
Licença:: Este trabalho é publicado pela Dove Medical Press Limited, e licenciado sob Creative Commons Atribuição - Uso Não-Comercial (portada, v3.0) License. Os termos completos da licença estão disponíveis em http://creativecommons.org/licenses/by-nc/3.0/ . Usos não comerciais de trabalho são permitidos sem qualquer permissão do Dove Medical Press Limited, desde que a obra seja devidamente atribuída.Permissões além do escopo da Licença são administrados por Dove Medical Press Limited. Informações sobre como solicitar a autorização pode ser encontrado em: http://www.dovepress.com/permissions.php. Fonte:<http://www.dovepress.com/preliminary-biocompatibility-investigation-of-magnetic-albumin-nanosph-peer-reviewed-article-IJN>. Acesso em: 03 fev. 2015.
Appears in Collections:CEL - Artigos publicados em periódicos

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