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Title: Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients
Authors: Lozano, Viviane Furlan
Lins, Tulio Cesar de Lima
Teixeira, Marcus de Melo
Vieira, Rodrigo G.
Blotta, Maria Heloisa de Souza Lima
Goes, Alfredo Miranda de
Silva, Izabel Cristina Rodrigues da
Pereira, Rinaldo Wellerson
Bocca, Anamélia Lorenzetti
Felipe, Maria Sueli Soares
Assunto:: Paracoccidioides brasiliensis
Paracoccidioidomicose
Fungos patogênicos
Issue Date: Mar-2011
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: LOZANO, Viviane F. et al. Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 2, mar. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200017&lng=pt&nrm=iso&tlng=en>. Acesso em: 21 mar. 2013. http://dx.doi.org/10.1590/S0074-02762011000200017.
Abstract: The CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1 and paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. For this purpose, 66 chronic form PCM patients and 76 healthy controls had their allele, genotype and haplotype frequencies determined. The genetic admixture structure of the patients and controls was evaluated to eliminate ancestral bias. The comparison of frequencies indicated no significant differences between patients and controls that could link the SNPs to PCM. Groups were admixture matched with no difference observed in population ancestry inference, indicating that the absence of association between CTLA-4 polymorphisms and PCM could not be attributed to ancestral bias. This study showed that there was no association between the CTLA-4 SNPs -318 and +49 and the resistance or susceptibility to PCM.
Licença:: Memórias do Instituto Oswaldo Cruz - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200017&lng=pt&nrm=iso&tlng=en. Acesso em: 21 mar. 2013.
DOI: http://dx.doi.org/10.1590/S0074-02762011000200017
Appears in Collections:CEL - Artigos publicados em periódicos
FCE-FAR - Artigos publicados em periódicos

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