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Título: Association between the -174 G/C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women
Autor(es): Nóbrega, Otávio de Tolêdo
Furioso, Audrey Cecília Tonet
Moraes, Clayton Franco
Gomes, Lucy Gomes
Karnikowski, Margô Gomes de Oliveira
Córdova, Claudio Olavo de Almeida
Karnikowski, Mauro
Assunto: Sistema cardiovascular - doenças
Coração - doenças
Idosos - cuidados médicos
Genética humana
Data de publicação: Jan-2008
Editora: Associação Brasileira de Divulgação Científica
Referência: NÓBREGA, O. T. Association between the -174 G/C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 41, n. 1, jan. 2008. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100008&lng=pt&nrm=iso>. Acesso em: 27 nov. 2012. http://dx.doi.org/10.1590/S0100-879X2006005000190.
Resumo: In worldwide studies, interleukin-6 (IL-6) is implicated in age-related disturbances. The aim of the present report was to determine the possible association of IL-6 -174 C/G promoter polymorphism with the cytokine profile as well as with the presence of selected cardiovascular risk features. This was a cross-sectional study on Brazilian women aged 60 years or older. A sample of 193 subjects was investigated for impaired glucose regulation, diabetes, hypertension, and dyslipidemia. Genotyping was done by direct sequencing of PCR products. IL-6 and C-reactive protein were quantified by high-sensitivity assays. General linear regression models or the Student t-test were used to compare continuous variables among genotypes, followed by adjustments for confounding variables. The chi-square test was used to compare categorical variables. The genotypes were consistent with Hardy-Weinberg equilibrium proportions. In a recessive model, mean waist-to-hip ratio, serum glycated hemoglobin and serum glucose were markedly lower in C homozygotes (P = 0.001, 0.028, and 0.047, respectively). In a dominant hypothesis, G homozygotes displayed a trend towards higher levels of circulating IL-6 (P = 0.092). Non-parametric analysis revealed that impaired fasting glucose and hypertension were findings approximately 2-fold more frequent among G homozygous subjects (P = 0.042 and 0.043, respectively). Taken together, our results show that the IL-6 -174 G-allele is implicated in a greater cardiovascular risk. To our knowledge, this is the first investigation of IL-6 promoter variants and age-related disturbances in the Brazilian elderly population.
Licença: Brazilian Journal of Medical and Biological Research - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=pt&nrm=iso. Acesso em: 27nov. 2012.
DOI: http://dx.doi.org/10.1590/S0100-879X2006005000190
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